Autoimmunity in membranous nephropathy targets aldose reductase and SOD2

M Prunotto, ML Carnevali, G Candiano… - Journal of the …, 2010 - journals.lww.com
Glomerular targets of autoimmunity in human membranous nephropathy are poorly
understood. Here, we used a combined proteomic approach to identify specific antibodies
against podocyte proteins in both serum and glomeruli of patients with membranous
nephropathy (MN). We detected specific anti–aldose reductase (AR) and anti–manganese
superoxide dismutase (SOD2) IgG 4 in sera of patients with MN. We also eluted high titers of
anti-AR and anti-SOD2 IgG 4 from microdissected glomeruli of three biopsies of MN kidneys …