Extracellular redox modulation by regulatory T cells
Z Yan, SK Garg, J Kipnis, R Banerjee - Nature chemical biology, 2009 - nature.com
Z Yan, SK Garg, J Kipnis, R Banerjee
Nature chemical biology, 2009•nature.comWe demonstrate that the mechanism of redox remodeling during mouse T-cell activation
involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine.
Extracellular cysteine accumulation results in a lower redox potential, which is conducive to
proliferation, and changes the net redox status of exofacial protein domains. Regulatory T
cells inhibit this redox metabolite signaling pathway, which represents a previously
unrecognized mechanism for immunosuppression of effector T cells.
involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine.
Extracellular cysteine accumulation results in a lower redox potential, which is conducive to
proliferation, and changes the net redox status of exofacial protein domains. Regulatory T
cells inhibit this redox metabolite signaling pathway, which represents a previously
unrecognized mechanism for immunosuppression of effector T cells.
Abstract
We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.
nature.com