[HTML][HTML] The platelet‐surface thiol isomerase enzyme ERp57 modulates platelet function
LM HOLBROOK, P Sasikumar, RG Stanley… - Journal of thrombosis …, 2012 - Elsevier
Background: Thiol isomerases are a family of endoplasmic reticulum enzymes which
orchestrate redox‐based modifications of protein disulphide bonds. Previous studies have
identified important roles for the thiol isomerases PDI and ERp5 in the regulation of normal
platelet function. Aim: Recently, we demonstrated the presence of a further five thiol
isomerases at the platelet surface. In this report we aim to report the role of one of these
enzymes–ERp57 in the regulation of platelet function. Methods/Results: Using enzyme …
orchestrate redox‐based modifications of protein disulphide bonds. Previous studies have
identified important roles for the thiol isomerases PDI and ERp5 in the regulation of normal
platelet function. Aim: Recently, we demonstrated the presence of a further five thiol
isomerases at the platelet surface. In this report we aim to report the role of one of these
enzymes–ERp57 in the regulation of platelet function. Methods/Results: Using enzyme …
