Myeloid-derived suppressor cells (MDSCs) represent a heterogenous collection of immature
myeloid cells endowed with suppressive function on the immune response. Their presence
has been extensively investigated in preclinical models, especially in the context of cancer.
One of the major obstacles in their accurate identification has been the definition of an
unambiguous phenotype, shared between mice and humans, and clearly correlating with
their suppressive function. In this paper, we review the literature concerning the phenotype …