Anti-oxidants prevent focal rat brain injury as assessed by induction of heat shock proteins (HSP70, HO-1/HSP32, HSP47) following subarachnoid injections of lysed …
CP Turner, SS Panter, FR Sharp - Molecular brain research, 1999 - Elsevier
The initial aim of this study was to determine if the HSP70 (the main inducible heat shock
protein), HO-1 (heme oxygenase-1, HSP32) and HSP47 (a collagen chaperone) stress
proteins were induced in the same focal regions of rat brain following experimental
subarachnoid hemorrhage (SAH). The next objective was to determine whether anti-
oxidants prevented the stress gene expression in the focal regions. Lysed blood (150 μl)
was injected into the subarachnoid space of adult, female Sprague–Dawley rats via the …
protein), HO-1 (heme oxygenase-1, HSP32) and HSP47 (a collagen chaperone) stress
proteins were induced in the same focal regions of rat brain following experimental
subarachnoid hemorrhage (SAH). The next objective was to determine whether anti-
oxidants prevented the stress gene expression in the focal regions. Lysed blood (150 μl)
was injected into the subarachnoid space of adult, female Sprague–Dawley rats via the …
