A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype
IB Kuznetsov, M McDuffie, R Moslehi - Bioinformatics, 2009 - academic.oup.com
IB Kuznetsov, M McDuffie, R Moslehi
Bioinformatics, 2009•academic.oup.comN-acetyltransferase-2 (NAT2) is an important enzyme that catalyzes the acetylation of
aromatic and heterocyclic amine carcinogens. Individuals in human populations are divided
into three NAT2 acetylator phenotypes: slow, rapid and intermediate. NAT2PRED is a web
server that implements a supervised pattern recognition method to infer NAT2 phenotype
from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803 and 857. The web server
can be used for a fast determination of NAT2 phenotypes in genetic screens. Availability …
aromatic and heterocyclic amine carcinogens. Individuals in human populations are divided
into three NAT2 acetylator phenotypes: slow, rapid and intermediate. NAT2PRED is a web
server that implements a supervised pattern recognition method to infer NAT2 phenotype
from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803 and 857. The web server
can be used for a fast determination of NAT2 phenotypes in genetic screens. Availability …
Abstract
Summary: N-acetyltransferase-2 (NAT2) is an important enzyme that catalyzes the acetylation of aromatic and heterocyclic amine carcinogens. Individuals in human populations are divided into three NAT2 acetylator phenotypes: slow, rapid and intermediate. NAT2PRED is a web server that implements a supervised pattern recognition method to infer NAT2 phenotype from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803 and 857. The web server can be used for a fast determination of NAT2 phenotypes in genetic screens.
Availability:Freely available at http://nat2pred.rit.albany.edu
Contact: ikuznetsov@albany.edu; rmoslehi@albany.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Oxford University Press