GSK3β is a negative regulator of the transcriptional coactivator MAML1
M Saint Just Ribeiro, ML Hansson… - Nucleic acids …, 2009 - academic.oup.com
M Saint Just Ribeiro, ML Hansson, MJ Lindberg, AE Popko-Ścibor, AE Wallberg
Nucleic acids research, 2009•academic.oup.comGlycogen synthase kinase 3β (GSK3β) is involved in several cellular signaling systems
through regulation of the activity of diverse transcription factors such as Notch, p53 and β-
catenin. Mastermind-like 1 (MAML1) was originally identified as a Notch coactivator, but has
also been reported to function as a transcriptional coregulator of p53, β-catenin and MEF2C.
In this report, we show that active GSK3β directly interacts with the MAML1 N-terminus and
decreases MAML1 transcriptional activity, suggesting that GSK3β might target a coactivator …
through regulation of the activity of diverse transcription factors such as Notch, p53 and β-
catenin. Mastermind-like 1 (MAML1) was originally identified as a Notch coactivator, but has
also been reported to function as a transcriptional coregulator of p53, β-catenin and MEF2C.
In this report, we show that active GSK3β directly interacts with the MAML1 N-terminus and
decreases MAML1 transcriptional activity, suggesting that GSK3β might target a coactivator …
Abstract
Glycogen synthase kinase 3β (GSK3β) is involved in several cellular signaling systems through regulation of the activity of diverse transcription factors such as Notch, p53 and β-catenin. Mastermind-like 1 (MAML1) was originally identified as a Notch coactivator, but has also been reported to function as a transcriptional coregulator of p53, β-catenin and MEF2C. In this report, we show that active GSK3β directly interacts with the MAML1 N-terminus and decreases MAML1 transcriptional activity, suggesting that GSK3β might target a coactivator in its regulation of gene expression. We have previously shown that MAML1 increases global acetylation of histones, and here we show that the GSK3 inhibitor SB41, further enhances MAML1-dependent histone acetylation in cells. Finally, MAML1 translocates GSK3β to nuclear bodies; this function requires full-length MAML1 protein.
Oxford University Press