Control of endothelial barrier function by regulating vascular endothelial-cadherin
D Vestweber, A Broermann… - Current opinion in …, 2010 - journals.lww.com
D Vestweber, A Broermann, D Schulte
Current opinion in hematology, 2010•journals.lww.comEndothelial cell contacts are regulated by a complex interplay between various receptors
and signaling mediators that control the plasticity of the cytoskeleton and the function of
junctional adhesion molecules. Knowing and understanding the essential players of this
network will allow development of agents that could prevent breakdown of the vascular
permeability barrier in shock or that could block leukocyte extravasation and thereby
antagonize inflammation.
and signaling mediators that control the plasticity of the cytoskeleton and the function of
junctional adhesion molecules. Knowing and understanding the essential players of this
network will allow development of agents that could prevent breakdown of the vascular
permeability barrier in shock or that could block leukocyte extravasation and thereby
antagonize inflammation.
Summary
Endothelial cell contacts are regulated by a complex interplay between various receptors and signaling mediators that control the plasticity of the cytoskeleton and the function of junctional adhesion molecules. Knowing and understanding the essential players of this network will allow development of agents that could prevent breakdown of the vascular permeability barrier in shock or that could block leukocyte extravasation and thereby antagonize inflammation.
Lippincott Williams & Wilkins