TGF-β plays a key role in upregulating matrix production in injury-induced renal fibrosis, but
how TGF-β signaling in distinct compartments of the kidney, such as specific segments of the
nephron, affects the response to injury is unknown. In this study, we determined the role of
TGF-β signaling both in development of the renal collecting system and in response to injury
by selectively deleting the TGF-β type II receptor in mice at the initiation of ureteric bud
development. These mice developed normally but demonstrated a paradoxic increase in …