Rapid detection of acute kidney injury by plasma and urinary neutrophil gelatinase-associated lipocalin after cardiopulmonary bypass
SM Tuladhar, VO Püntmann, M Soni… - Journal of …, 2009 - journals.lww.com
Journal of cardiovascular pharmacology, 2009•journals.lww.com
Background: Cardiopulmonary bypass (CPB) is associated with a significant risk of
postoperative renal dysfunction. We studied the utility of a novel biomarker in predicting
acute kidney injury (AKI) in adult patients undergoing cardiac surgery. Methods and Results:
Blood and urine were obtained from 50 patients undergoing CPB-requiring surgery. Patients
were divided into group A (n= 41) with normal creatinine pre-bypass and post-bypass and
group B (n= 9) who developed an increase in serum creatinine of> 0.5 mg/dL within the first …
postoperative renal dysfunction. We studied the utility of a novel biomarker in predicting
acute kidney injury (AKI) in adult patients undergoing cardiac surgery. Methods and Results:
Blood and urine were obtained from 50 patients undergoing CPB-requiring surgery. Patients
were divided into group A (n= 41) with normal creatinine pre-bypass and post-bypass and
group B (n= 9) who developed an increase in serum creatinine of> 0.5 mg/dL within the first …
Abstract
Background:
Cardiopulmonary bypass (CPB) is associated with a significant risk of postoperative renal dysfunction. We studied the utility of a novel biomarker in predicting acute kidney injury (AKI) in adult patients undergoing cardiac surgery.
Methods and Results:
Blood and urine were obtained from 50 patients undergoing CPB-requiring surgery. Patients were divided into group A (n= 41) with normal creatinine pre-bypass and post-bypass and group B (n= 9) who developed an increase in serum creatinine of> 0.5 mg/dL within the first 48 hours post CPB. Plasma and urinary neutrophil gelatinase-associated lipocalin (NGAL) was determined at baseline and 2 hours after CPB.
Lippincott Williams & Wilkins