Background Although intrathecal administration of midazolam has been found to produce
analgesia, how midazolam exerts this effect is not understood fully at the neuronal level in
the spinal cord. Methods The effects of midazolam on either electrically evoked or
spontaneous inhibitory transmission and on a response to exogenous gamma-aminobutyric
acid (GABA), a GABA (A)-receptor agonist, muscimol, or glycine were evaluated in
substantia gelatinosa neurons of adult rat spinal cord slices by using the whole-cell patch …