Convulsions and refractory ventricular fibrillation after intrathecal injection of a massive dose of tranexamic acid
HM Yeh, HP Lau, PL Lin, WZ Sun… - The Journal of the …, 2003 - pubs.asahq.org
Discussion Tranexamic acid has a low acute toxicity at therapeutic doses. The lethal oral
dose exceeds 3–10 g/kg body weight in all species studied, and the 50% lethal dose after
intravenous injection is approximately 1–1.5 g/kg body weight in mice, rats, rabbits, and
dogs. 3 However, when applied topically to the cerebral cortex in animal studies, tranexamic
acid produced powerful seizures. 4–6
dose exceeds 3–10 g/kg body weight in all species studied, and the 50% lethal dose after
intravenous injection is approximately 1–1.5 g/kg body weight in mice, rats, rabbits, and
dogs. 3 However, when applied topically to the cerebral cortex in animal studies, tranexamic
acid produced powerful seizures. 4–6
