Convulsive seizures following subdural application of fibrin sealant containing tranexamic acid in a rat model
MG Schlag, R Hopf, H Redl - Neurosurgery, 2000 - journals.lww.com
OBJECTIVES Tranexamic acid (t-AMCA) has been shown to cause severe convulsions in
humans and cats when applied topically to the central nervous system. We wanted to
determine whether pure t-AMCA or fibrin sealant (FS) containing t-AMCA would induce
similar effects when applied to the spinal cord in a rat model. METHODS Following low-
thoracic laminectomy, the dura was incised to expose the dorsal surface of the lumbar
enlargement. Rats were allocated to one of the following treatments: 1) t-AMCA (10 mg/ml) …
humans and cats when applied topically to the central nervous system. We wanted to
determine whether pure t-AMCA or fibrin sealant (FS) containing t-AMCA would induce
similar effects when applied to the spinal cord in a rat model. METHODS Following low-
thoracic laminectomy, the dura was incised to expose the dorsal surface of the lumbar
enlargement. Rats were allocated to one of the following treatments: 1) t-AMCA (10 mg/ml) …
