Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial …
MN Alvarez, G Peluffo, L Piacenza, R Radi - Journal of Biological Chemistry, 2011 - ASBMB
Macrophage-derived radicals generated by the NADPH oxidase complex and inducible
nitric-oxide synthase (iNOS) participate in cytotoxic mechanisms against microorganisms.
Nitric oxide (• NO) plays a central role in the control of acute infection by Trypanosoma cruzi,
the causative agent of Chagas disease, and we have proposed that much of its action relies
on macrophage-derived peroxynitrite (ONOO−+ ONOOH) formation, a strong oxidant arising
from the reaction of• NO with superoxide radical (O 2 ̇̄). Herein, we have shown that …
nitric-oxide synthase (iNOS) participate in cytotoxic mechanisms against microorganisms.
Nitric oxide (• NO) plays a central role in the control of acute infection by Trypanosoma cruzi,
the causative agent of Chagas disease, and we have proposed that much of its action relies
on macrophage-derived peroxynitrite (ONOO−+ ONOOH) formation, a strong oxidant arising
from the reaction of• NO with superoxide radical (O 2 ̇̄). Herein, we have shown that …
