Identification of β-1, 4-galactosyltransferase I as a target gene of HBx-induced cell cycle progression of hepatoma cell
BACKGROUND/AIMS: The hepatitis B virus-encoded HBx protein contributes to
hepatocarcinogenesis with largely unknown mechanisms. It is widely known that N-linked
oligosaccharides on glycoproteins are structurally altered during malignant transformation
and these alterations are often associated with malignant transformation of cells. β-1, 4-
galactosyltransferase I (GalT I) contributes to the biosynthesis of Galβ→ 4GlcNAc structure in
the outer chain moieties of N-glycans. METHODS: The difference of GalT I expression …
hepatocarcinogenesis with largely unknown mechanisms. It is widely known that N-linked
oligosaccharides on glycoproteins are structurally altered during malignant transformation
and these alterations are often associated with malignant transformation of cells. β-1, 4-
galactosyltransferase I (GalT I) contributes to the biosynthesis of Galβ→ 4GlcNAc structure in
the outer chain moieties of N-glycans. METHODS: The difference of GalT I expression …
