[HTML][HTML] A local increase in red blood cell aggregation can trigger deep vein thrombosis: evidence based on quantitative cellular ultrasound imaging
FTH Yu, JK Armstrong, J Tripette, HJ Meiselman… - Journal of thrombosis …, 2011 - Elsevier
Background: Recurrent deep vein thrombosis (DVT) risk factors include a first idiopathic
DVT, strongly suggesting the existence of undiagnosed and/or unidentified prothrombotic
abnormalities. Objectives: To evaluate the impact of locally increased red blood cell (RBC)
aggregation on DVT pathogenesis in a rabbit model. Methods: DVT presence, flow and
aggregation were measured in situ with ultrasound. Greatly enhanced aggregation was
achieved by covalent linkage of Pluronic F98 to the RBC surface; coating with Pluronic F68 …
DVT, strongly suggesting the existence of undiagnosed and/or unidentified prothrombotic
abnormalities. Objectives: To evaluate the impact of locally increased red blood cell (RBC)
aggregation on DVT pathogenesis in a rabbit model. Methods: DVT presence, flow and
aggregation were measured in situ with ultrasound. Greatly enhanced aggregation was
achieved by covalent linkage of Pluronic F98 to the RBC surface; coating with Pluronic F68 …