Increased microparticle tissue factor activity in cancer patients with venous thromboembolism
DA Manly, J Wang, SL Glover, R Kasthuri… - Thrombosis research, 2010 - Elsevier
Cancer patients exhibit a high rate of thromboembolism (VTE). In this study, we analyzed
levels of microparticle (MP) tissue factor (TF) activity in cancer patients with or without VTE.
Blood was collected from cancer patients within 24 h of objectively diagnosed VTE (n= 53)
and from cancer patients without VTE (n= 13). MPs were isolated from platelet poor plasma
by centrifugation at 20,000 g for 15 min. MP TF activity was measured using a two-stage
chromogenic assay. Cancer patients with VTE had a significantly higher mean MP TF activity …
levels of microparticle (MP) tissue factor (TF) activity in cancer patients with or without VTE.
Blood was collected from cancer patients within 24 h of objectively diagnosed VTE (n= 53)
and from cancer patients without VTE (n= 13). MPs were isolated from platelet poor plasma
by centrifugation at 20,000 g for 15 min. MP TF activity was measured using a two-stage
chromogenic assay. Cancer patients with VTE had a significantly higher mean MP TF activity …