[HTML][HTML] Microparticle‐associated tissue factor activity: a link between cancer and thrombosis?
MET Tesselaar, F Romijn, IK Van Der Linden… - Journal of thrombosis …, 2007 - Elsevier
Background: Cancer, in particular mucinous adenocarcinoma, is associated with venous
thromboembolism (VTE). Tissue factor (TF), initiator of coagulation, plays a central role in the
paradigm that clotting and tumor growth form a vicious circle, in which hypercoagulability
facilitates the aggressive biology of cancer and vice versa. Expression of TF in tumors is
associated with poor differentiation and poor prognosis. Patient/methods: We investigated
the association between clinically manifest VTE and procoagulant properties of circulating …
thromboembolism (VTE). Tissue factor (TF), initiator of coagulation, plays a central role in the
paradigm that clotting and tumor growth form a vicious circle, in which hypercoagulability
facilitates the aggressive biology of cancer and vice versa. Expression of TF in tumors is
associated with poor differentiation and poor prognosis. Patient/methods: We investigated
the association between clinically manifest VTE and procoagulant properties of circulating …