Intravascular fibrin deposition is believed to play an important role in the development of
intimal hyperplasia, which is a hallmark of several human vascular disorders, including
atherosclerosis and restenosis after balloon angioplasty. Plasminogen activator inhibitor-1
(PAI-1), the primary inhibitor or tissue-and urinary-type plasminogen activator, plays a key
role in fibrin homeostasis by controlling plasmin formation. PAI-1 may also modulate
vascular pathology via alternative pathways, such as inhibiting activated protein C and …