Chronic venous insufficiency resulting in post-thrombotic syndrome occurs commonly after
acute deep vein thrombosis, and is a prevalent cause of vascular disease morbidity in the
community. Therefore, a better understanding of the pathophysiologic mechanisms that
promote the development of chronic venous insufficiency could lead to novel approaches to
interrupt the natural history and prevent post-thrombotic syndrome. In this paper, we will
review the evidence that venous thrombus resolution is an inflammatory process that is …