Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
TH Stracker, T Usui, JHJ Petrini - DNA repair, 2009 - Elsevier
The cellular DNA damage response (DDR) is activated by many types of DNA lesions. Upon
recognition of DNA damage by sensor proteins, an intricate signal transduction network is
activated to coordinate diverse cellular outcomes that promote genome integrity. Key
components of the DDR in mammalian cells are the checkpoint effector kinases Chk1 and
Chk2 (referred to henceforth as the effector kinases; orthologous to spChk1 and spCds1 in
the fission yeast S. pombe and scChk1 and scRad53 in the budding yeast S. cerevisiae) …
recognition of DNA damage by sensor proteins, an intricate signal transduction network is
activated to coordinate diverse cellular outcomes that promote genome integrity. Key
components of the DDR in mammalian cells are the checkpoint effector kinases Chk1 and
Chk2 (referred to henceforth as the effector kinases; orthologous to spChk1 and spCds1 in
the fission yeast S. pombe and scChk1 and scRad53 in the budding yeast S. cerevisiae) …
