Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells
T Nagata, L Mckinley, JJ Peschon… - The Journal of …, 2008 - journals.aai.org
The Journal of Immunology, 2008•journals.aai.org
Th17 cells, a subset of T cells involved in autoimmunity and host defense against
extracellular Gram-negative infection, express both IL-17A and IL-17F. Both IL-17A and IL-
17F can signal via the IL-17RA; however, IL-17F does so at a 1-to 2-log higher concentration
than IL-17A. In this study, we show that the IL-17F homodimer via IL-17RA is a negative
regulator of IL-17 production in T cells and suggest a mechanism whereby IL-17RA on T
cells serves as an autocrine/paracrine regulator of IL-17 synthesis in T cells.
extracellular Gram-negative infection, express both IL-17A and IL-17F. Both IL-17A and IL-
17F can signal via the IL-17RA; however, IL-17F does so at a 1-to 2-log higher concentration
than IL-17A. In this study, we show that the IL-17F homodimer via IL-17RA is a negative
regulator of IL-17 production in T cells and suggest a mechanism whereby IL-17RA on T
cells serves as an autocrine/paracrine regulator of IL-17 synthesis in T cells.
Abstract
Th17 cells, a subset of T cells involved in autoimmunity and host defense against extracellular Gram-negative infection, express both IL-17A and IL-17F. Both IL-17A and IL-17F can signal via the IL-17RA; however, IL-17F does so at a 1-to 2-log higher concentration than IL-17A. In this study, we show that the IL-17F homodimer via IL-17RA is a negative regulator of IL-17 production in T cells and suggest a mechanism whereby IL-17RA on T cells serves as an autocrine/paracrine regulator of IL-17 synthesis in T cells.
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