Growth and Differentiation of Transplanted W/Wv Marrow
JP Lewis, LF O'GRADY, SE Bernstein, ES Russell… - Blood, 1967 - ashpublications.org
JP Lewis, LF O'GRADY, SE Bernstein, ES Russell, FE Trobaugh Jr
Blood, 1967•ashpublications.orgThis paper reports new data on the effect of the action of the mutant genes W and Wv on
murine hemopoiesis. Our studies demonstrate that the presence of these mutant genes
produces:(1) a macrocytic anemia with neither granulocytopenia nor thrombocytopenia;(2) a
severe defect in the early stages of hemopoietic repopulation manifested by (a) an apparent
block in the differentiation of immature cells into erythroid precursors, and (b) a greatly
reduced rate of proliferation of differentiated hemopoietic elements. These data demonstrate …
murine hemopoiesis. Our studies demonstrate that the presence of these mutant genes
produces:(1) a macrocytic anemia with neither granulocytopenia nor thrombocytopenia;(2) a
severe defect in the early stages of hemopoietic repopulation manifested by (a) an apparent
block in the differentiation of immature cells into erythroid precursors, and (b) a greatly
reduced rate of proliferation of differentiated hemopoietic elements. These data demonstrate …
Abstract
This paper reports new data on the effect of the action of the mutant genes W and Wv on murine hemopoiesis. Our studies demonstrate that the presence of these mutant genes produces: (1) a macrocytic anemia with neither granulocytopenia nor thrombocytopenia; (2) a severe defect in the early stages of hemopoietic repopulation manifested by (a) an apparent block in the differentiation of immature cells into erythroid precursors, and (b) a greatly reduced rate of proliferation of differentiated hemopoietic elements.
These data demonstrate the existence of genetic influence on repopulation and differentiation of transplanted marrow and suggest that severe anemia may result not only from defects in the late stages of erythroid development but also from abnormalities in the early stages of erythroid maturation and hemopoietic repopulation.
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