[HTML][HTML] The impact of immunological parameters on the development of phantom pain after major amputation
C Stremmel, C Horn, S Eder, A Dimmler… - European journal of …, 2005 - Elsevier
C Stremmel, C Horn, S Eder, A Dimmler, W Lang
European journal of vascular and endovascular surgery, 2005•ElsevierOBJECTIVES: To investigate the relationship between local and systemic inflammatory
markers and phantom limb pain. METHODS: In 39 consecutive patients undergoing major
amputations nerve biopsies, serum and clinical data was collected. Patients were followed
up for 12 months to report on the incidence and severity of phantom limb pain. RESULTS:
After 12 months, 78% of the surviving patients had phantom pain, the symptom usually
commencing within 14 days of operation. The severity of macrophage infiltration within the …
markers and phantom limb pain. METHODS: In 39 consecutive patients undergoing major
amputations nerve biopsies, serum and clinical data was collected. Patients were followed
up for 12 months to report on the incidence and severity of phantom limb pain. RESULTS:
After 12 months, 78% of the surviving patients had phantom pain, the symptom usually
commencing within 14 days of operation. The severity of macrophage infiltration within the …
OBJECTIVES
To investigate the relationship between local and systemic inflammatory markers and phantom limb pain.
METHODS
In 39 consecutive patients undergoing major amputations nerve biopsies, serum and clinical data was collected. Patients were followed up for 12 months to report on the incidence and severity of phantom limb pain.
RESULTS
After 12 months, 78% of the surviving patients had phantom pain, the symptom usually commencing within 14 days of operation. The severity of macrophage infiltration within the nerve biopsy was negatively correlated to the inception of phantom pain (P=0.026). While serum TNF-alpha concentration was positively correlated to mortality (P=0.021).
CONCLUSIONS
The immune status existing before the amputation and the local immunological milieu influence the onset of phantom pain.
Elsevier
