Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells
A Brack, HL Rittner, H Machelska, K Leder, SA Mousa… - Pain, 2004 - Elsevier
Opioid-containing leukocytes can counteract inflammatory hyperalgesia. Under stress or
after local injection of corticotropin releasing factor (CRF), opioid peptides are released from
leukocytes, bind to opioid receptors on peripheral sensory neurons and mediate
antinociception. Since polymorphonuclear cells (PMN) are the predominant opioid-
containing leukocyte subpopulation in early inflammation, we hypothesized that PMN and
their recruitment by chemokines are important for peripheral opioid-mediated …
after local injection of corticotropin releasing factor (CRF), opioid peptides are released from
leukocytes, bind to opioid receptors on peripheral sensory neurons and mediate
antinociception. Since polymorphonuclear cells (PMN) are the predominant opioid-
containing leukocyte subpopulation in early inflammation, we hypothesized that PMN and
their recruitment by chemokines are important for peripheral opioid-mediated …
