[HTML][HTML] The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the …
M Bachmann, H Hennemann, PX Xing… - Journal of Biological …, 2004 - ASBMB
The Pim-1 oncogene encodes a serine-threonine kinase that relays signals from cytokine
receptors and contributes to the formation of lymphoid tumors when expressed at high
levels. Here we show that the protein kinase Cdc25 C-associated kinase 1 (C-TAK1) is a
binding partner and a substrate of Pim-1. A physical interaction of Pim-1 and C-TAK1 could
be shown biochemically and in yeast two-hybrid assays. Immunofluorescence experiments
suggested that Pim-1· C-TAK1 complexes are predominantly cytoplasmic. When transiently …
receptors and contributes to the formation of lymphoid tumors when expressed at high
levels. Here we show that the protein kinase Cdc25 C-associated kinase 1 (C-TAK1) is a
binding partner and a substrate of Pim-1. A physical interaction of Pim-1 and C-TAK1 could
be shown biochemically and in yeast two-hybrid assays. Immunofluorescence experiments
suggested that Pim-1· C-TAK1 complexes are predominantly cytoplasmic. When transiently …
