[HTML][HTML] Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor …
Y Takayama, P May, RGW Anderson, J Herz - Journal of Biological …, 2005 - ASBMB
The low density lipoprotein receptor-related protein 1 (LRP1) has been implicated in
intracellular signaling functions as well as in lipid metabolism. Recent in vivo and in vitro
studies suggest that LRP1 is a physiological modulator of the platelet-derived growth factor
(PDGF) signaling pathway. Here we show that in mouse fibroblasts LRP1 modulates PDGF-
BB signaling by controlling endocytosis and ligand-induced down-regulation of the PDGF
receptor β (PDGFRβ). In LRP1-deficient fibroblasts, basal PDGFRβ tyrosine kinase activity …
intracellular signaling functions as well as in lipid metabolism. Recent in vivo and in vitro
studies suggest that LRP1 is a physiological modulator of the platelet-derived growth factor
(PDGF) signaling pathway. Here we show that in mouse fibroblasts LRP1 modulates PDGF-
BB signaling by controlling endocytosis and ligand-induced down-regulation of the PDGF
receptor β (PDGFRβ). In LRP1-deficient fibroblasts, basal PDGFRβ tyrosine kinase activity …