[HTML][HTML] Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells
YJ Suzuki, RM Day, CC Tan, TH Sandven… - Journal of Biological …, 2003 - ASBMB
Serotonin (5-hydroxytryptamine (5-HT)) is a mitogen of pulmonary artery smooth muscle
cells (PASMC) and plays an important role in the development of pulmonary hypertension.
Signal transduction initiated by 5-HT involves serotonin transporter-dependent generation of
reactive oxygen species and activation of the MEK-ERK pathway. However, the downstream
transcriptional regulatory components have not been identified. In systemic smooth muscle
cells, GATA-6 has been shown to regulate mitogenesis by driving cells into a quiescent …
cells (PASMC) and plays an important role in the development of pulmonary hypertension.
Signal transduction initiated by 5-HT involves serotonin transporter-dependent generation of
reactive oxygen species and activation of the MEK-ERK pathway. However, the downstream
transcriptional regulatory components have not been identified. In systemic smooth muscle
cells, GATA-6 has been shown to regulate mitogenesis by driving cells into a quiescent …