1. Adenosine is a normal constituent of all body fluids and its levels are raised, for example,
by hypoxia and ischemia. In addition, both adenosine and ATP can be released by
endothelial cells and neutrophils in response to physiologic stimulation. 2. 2. Human
neutrophil leukocytes possess multiple adenosine receptors and P 2 purinoceptors. 3. 3.
ATP can increase intracellular Ca 2+ levels in neutrophils, cause degranulation and enzyme
release, potentiate the oxidative burst and enhance their adhesion to the endothelium. ATP …