Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase
P Lebrun, MR Montminy, E Van Obberghen - Journal of biological chemistry, 2005 - ASBMB
The transcription factor PDX-1 plays a crucial role during pancreatic development and in the
function of insulin-producing beta cells. Disruption of the pdx-1 gene in these cells induces
overt diabetes in mice, and this gene is modified in several type 2 diabetic families. It is thus
crucial to determine the molecular mechanisms involved in the regulation of PDX-1
expression and/or activation. We identified new proteins associated with PDX-1 by mass
spectrometry. These proteins, Ku70 and Ku80, are regulatory subunits of DNA-dependent …
function of insulin-producing beta cells. Disruption of the pdx-1 gene in these cells induces
overt diabetes in mice, and this gene is modified in several type 2 diabetic families. It is thus
crucial to determine the molecular mechanisms involved in the regulation of PDX-1
expression and/or activation. We identified new proteins associated with PDX-1 by mass
spectrometry. These proteins, Ku70 and Ku80, are regulatory subunits of DNA-dependent …
