Islet amyloid polypeptide and type 2 diabetes
L Marzban, K Park, CB Verchere - Experimental gerontology, 2003 - Elsevier
Type 2 diabetes is associated with progressive β-cell failure manifest as a decline in insulin
secretion and increasing hyperglycemia. A growing body of evidence suggests that β-cell
failure in type 2 diabetes correlates with the formation of pancreatic islet amyloid deposits,
indicating that islet amyloid may have an important role in β-cell loss in this disease. Islet
amyloid polypeptide (IAPP; amylin), the major component of islet amyloid, is co-secreted
with insulin from β-cells. In type 2 diabetes, this peptide aggregates to form amyloid fibrils …
secretion and increasing hyperglycemia. A growing body of evidence suggests that β-cell
failure in type 2 diabetes correlates with the formation of pancreatic islet amyloid deposits,
indicating that islet amyloid may have an important role in β-cell loss in this disease. Islet
amyloid polypeptide (IAPP; amylin), the major component of islet amyloid, is co-secreted
with insulin from β-cells. In type 2 diabetes, this peptide aggregates to form amyloid fibrils …
