[HTML][HTML] β-Cell adaptation to insulin resistance: increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats
YQ Liu, TL Jetton, JL Leahy - Journal of Biological Chemistry, 2002 - ASBMB
The β-cell biochemical mechanisms that account for the compensatory hyperfunction with
insulin resistance (so-calledβ-cell adaptation) are unknown. We investigated glucose
metabolism in isolated islets from 10–12-week-old Zucker fatty (ZF) and Zucker lean (ZL)
rats (results expressed per mg/islet of protein). ZF rats were obese, hyperlipidemic, and
normoglycemic. They had a 3.8-fold increased β-cell mass along with 3–10-fold increases in
insulin secretion to various stimuli during pancreas perfusion despite insulin content per …
insulin resistance (so-calledβ-cell adaptation) are unknown. We investigated glucose
metabolism in isolated islets from 10–12-week-old Zucker fatty (ZF) and Zucker lean (ZL)
rats (results expressed per mg/islet of protein). ZF rats were obese, hyperlipidemic, and
normoglycemic. They had a 3.8-fold increased β-cell mass along with 3–10-fold increases in
insulin secretion to various stimuli during pancreas perfusion despite insulin content per …
