[HTML][HTML] Whole-body protein anabolic response is resistant to the action of insulin in obese women
S Chevalier, EB Marliss, JA Morais, M Lamarche… - The American journal of …, 2005 - Elsevier
Background: Obesity is associated with insulin resistance of glucose and lipid metabolism.
Objective: We sought to determine the effects of obesity on the insulin sensitivity of protein
metabolism. Design: Whole-body [13 C] leucine and [3 H] glucose kinetics were measured
in 9 lean and 10 obese women in the postabsorptive state and during a hyperinsulinemic,
euglycemic, isoaminoacidemic clamp. Results: In the postabsorptive state, the leucine
endogenous rate of appearance (catabolism), normalized for fat-free mass, was 11% greater …
Objective: We sought to determine the effects of obesity on the insulin sensitivity of protein
metabolism. Design: Whole-body [13 C] leucine and [3 H] glucose kinetics were measured
in 9 lean and 10 obese women in the postabsorptive state and during a hyperinsulinemic,
euglycemic, isoaminoacidemic clamp. Results: In the postabsorptive state, the leucine
endogenous rate of appearance (catabolism), normalized for fat-free mass, was 11% greater …