[HTML][HTML] Tissue-specific autoregulation of the LXRα gene facilitates induction of apoE in mouse adipose tissue
The functions of the liver X receptors (LXRs) are not well documented in adipose tissue. We
demonstrate here that expression of the LXRα gene is highly induced in vivo and in vitro in
mouse and human adipocytes in the presence of the synthetic LXR agonist T0901317. This
autoregulation is caused by an identified LXR-responsive element motif in the mouse LXRα
promoter, which is conserved in the human LXRα promoter. Using different LXR-deficient
mice, we demonstrate that the basal expression level of LXRα is increased in LXRβ−/− mice …
demonstrate here that expression of the LXRα gene is highly induced in vivo and in vitro in
mouse and human adipocytes in the presence of the synthetic LXR agonist T0901317. This
autoregulation is caused by an identified LXR-responsive element motif in the mouse LXRα
promoter, which is conserved in the human LXRα promoter. Using different LXR-deficient
mice, we demonstrate that the basal expression level of LXRα is increased in LXRβ−/− mice …
