[HTML][HTML] Deregulated expression of c-myc in megakaryocytes of transgenic mice increases megakaryopoiesis and decreases polyploidization
A Thompson, Y Zhang, D Kamen, CW Jackson… - Journal of Biological …, 1996 - ASBMB
Platelets, essential for vascular integrity and hemostasis, fragment from polyploid
megakaryocytes, characterized by their endomitotic cell cycle. We studied the influence of
overexpression of c-myc oncogene on megakaryopoiesis and endomitosis in vivo, using
transgenic mice carrying c-myc fused to the estrogen receptor under the control of the
platelet factor 4 (PF4) megakaryocyte-specific promoter. The rationale behind this strategy
was to obtain controlled overexpression of an active c-Myc, depending on the estrogen level …
megakaryocytes, characterized by their endomitotic cell cycle. We studied the influence of
overexpression of c-myc oncogene on megakaryopoiesis and endomitosis in vivo, using
transgenic mice carrying c-myc fused to the estrogen receptor under the control of the
platelet factor 4 (PF4) megakaryocyte-specific promoter. The rationale behind this strategy
was to obtain controlled overexpression of an active c-Myc, depending on the estrogen level …
