[HTML][HTML] Simian virus 40 large T antigen binds a novel Bcl-2 homology domain 3-containing proapoptosis protein in the cytoplasm
SC Tsai, KBS Pasumarthi, L Pajak, M Franklin… - Journal of Biological …, 2000 - ASBMB
A 193-kDa SV40 large T antigen (T-Ag)-binding protein, designated p193, was identified
and cloned. Inspection of the deduced amino acid sequence revealed the presence of a
short motif similar to the Bcl-2 homology (BH) domain 3, suggesting that p193 may be a
member of a family of apoptosis promoting proteins containing only BH3 motifs. In support of
this, p193 expression promoted apoptosis in NIH-3T3 cells. Deletion of the BH3 motif
abolished p193 apoptosis activity. p193-induced apoptosis was antagonized by co …
and cloned. Inspection of the deduced amino acid sequence revealed the presence of a
short motif similar to the Bcl-2 homology (BH) domain 3, suggesting that p193 may be a
member of a family of apoptosis promoting proteins containing only BH3 motifs. In support of
this, p193 expression promoted apoptosis in NIH-3T3 cells. Deletion of the BH3 motif
abolished p193 apoptosis activity. p193-induced apoptosis was antagonized by co …
