A method that allows easy characterization of tumor-infiltrating lymphocytes
DW Kowalczyk, AP Wlazlo, M Blaszczyk-Thurin… - Journal of …, 2001 - Elsevier
A method was developed to compare the lymphocytic infiltrates in regressing vs.
progressing experimental mouse tumors using a model for human papillomavirus-16 (HPV-
16) oncoprotein-linked cancer. Tumor cells mixed with matrigel, composed of natural matrix
substances that provide a basement membrane structure for adherent cells, were inoculated
into mice vaccinated with an efficacious vaccine to the E7 oncoprotein or a vaccine to a
control antigen. The tumor cells remained within the solidified gel and recruited a cellular …
progressing experimental mouse tumors using a model for human papillomavirus-16 (HPV-
16) oncoprotein-linked cancer. Tumor cells mixed with matrigel, composed of natural matrix
substances that provide a basement membrane structure for adherent cells, were inoculated
into mice vaccinated with an efficacious vaccine to the E7 oncoprotein or a vaccine to a
control antigen. The tumor cells remained within the solidified gel and recruited a cellular …
