[HTML][HTML] Priming of human neutrophil respiratory burst by granulocyte/macrophage colony-stimulating factor (GM-CSF) involves partial phosphorylation of p47 phox
PMC Dang, C Dewas, M Gaudry, M Fay… - Journal of Biological …, 1999 - ASBMB
Neutrophil superoxide production can be potentiated by prior exposure to" priming" agents
such as granulocyte/macrophage colony stimulating factor (GM-CSF). Because the
mechanism underlying GM-CSF-dependent priming is not understood, we investigated the
effects of GM-CSF on the phosphorylation of the cytosolic NADPH oxidase components p47
phox and p67 phox. Preincubation of neutrophils with GM-CSF alone increased the
phosphorylation of p47 phox but not that of p67 phox. Addition of formyl-methionyl-leucyl …
such as granulocyte/macrophage colony stimulating factor (GM-CSF). Because the
mechanism underlying GM-CSF-dependent priming is not understood, we investigated the
effects of GM-CSF on the phosphorylation of the cytosolic NADPH oxidase components p47
phox and p67 phox. Preincubation of neutrophils with GM-CSF alone increased the
phosphorylation of p47 phox but not that of p67 phox. Addition of formyl-methionyl-leucyl …
