[HTML][HTML] Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca2//calmodulin-dependent kinase II promotes depolarization …
DA Linseman, CM Bartley, SS Le, TA Laessig… - Journal of Biological …, 2003 - ASBMB
Cerebellar granule neuron (CGN) survival depends on activity of the myocyte enhancer
factor-2 (MEF2) transcription factors. Neuronal MEF2 activity is regulated by depolarization
via a mechanism that is presently unclear. Here, we show that depolarization-mediated
MEF2 activity and CGN survival are compromised by overexpression of the MEF2 repressor
histone deacetylase-5 (HDAC5). Furthermore, removal of depolarization induced rapid
cytoplasm-to-nuclear translocation of endogenous HDAC5. This effect was mimicked by …
factor-2 (MEF2) transcription factors. Neuronal MEF2 activity is regulated by depolarization
via a mechanism that is presently unclear. Here, we show that depolarization-mediated
MEF2 activity and CGN survival are compromised by overexpression of the MEF2 repressor
histone deacetylase-5 (HDAC5). Furthermore, removal of depolarization induced rapid
cytoplasm-to-nuclear translocation of endogenous HDAC5. This effect was mimicked by …
