[HTML][HTML] Calcium/calmodulin-dependent protein kinase activates serum response factor transcription activity by its dissociation from histone deacetylase, HDAC4 …
FJ Davis, M Gupta, B Camoretti-Mercado… - Journal of Biological …, 2003 - ASBMB
Serum response factor (SRF) plays a pivotal role in cardiac myocyte development, muscle
gene transcription, and hypertrophy. Previously, elevation of intracellular levels of Ca 2+
was shown to activate SRF function without involving the Ets family of tertiary complex
factors through an unknown regulatory mechanism. Here, we tested the hypothesis that the
chromatin remodeling enzymes of class II histone deacetylases (HDAC4) regulate SRF
activity in a Ca 2+-sensitive manner. Expression of HDAC4 profoundly repressed SRF …
gene transcription, and hypertrophy. Previously, elevation of intracellular levels of Ca 2+
was shown to activate SRF function without involving the Ets family of tertiary complex
factors through an unknown regulatory mechanism. Here, we tested the hypothesis that the
chromatin remodeling enzymes of class II histone deacetylases (HDAC4) regulate SRF
activity in a Ca 2+-sensitive manner. Expression of HDAC4 profoundly repressed SRF …
