Mechanisms and consequences of activation of protein kinase B/Akt
J Downward - Current opinion in cell biology, 1998 - Elsevier
Current opinion in cell biology, 1998•Elsevier
Protein kinase B (PKB)/Akt is a growth-factor-regulated serine/threonine kinase which
contains a pleckstrin homology domain. Binding of phosphoinositide 3-OH kinase products
to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma
membrane where it is activated by phosphorylation by upstream kinases including the
phosphoinoside-dependent kinase 1 (PDK1). Activated PKB/Akt provides a survival signal
that protects cells from apoptosis induced by various stresses, and also mediates a number …
contains a pleckstrin homology domain. Binding of phosphoinositide 3-OH kinase products
to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma
membrane where it is activated by phosphorylation by upstream kinases including the
phosphoinoside-dependent kinase 1 (PDK1). Activated PKB/Akt provides a survival signal
that protects cells from apoptosis induced by various stresses, and also mediates a number …
Protein kinase B (PKB)/Akt is a growth-factor-regulated serine/threonine kinase which contains a pleckstrin homology domain. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1). Activated PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, and also mediates a number of metabolic effects of insulin.
Elsevier