PVN galanin increases fat storage and promotes obesity by causing muscle to utilize carbohydrate more than fat
R Yun, JT Dourmashkin, J Hill, EC Gayles, SK Fried… - Peptides, 2005 - Elsevier
To understand the function of the feeding-stimulatory peptide, galanin (GAL), in eating and
body weight regulation, the present experiments tested the effects of both acute and chronic
injections of this peptide into the paraventricular nucleus (PVN) of rats. With food absent
during the test, acute injection of GAL (300pmol/0.3 μl) significantly increased
phosphofructokinase activity in muscle, suggesting enhanced capacity to metabolize
carbohydrate, and reduced circulating glucose levels. It also decreased β-hydroxyacyl-CoA …
body weight regulation, the present experiments tested the effects of both acute and chronic
injections of this peptide into the paraventricular nucleus (PVN) of rats. With food absent
during the test, acute injection of GAL (300pmol/0.3 μl) significantly increased
phosphofructokinase activity in muscle, suggesting enhanced capacity to metabolize
carbohydrate, and reduced circulating glucose levels. It also decreased β-hydroxyacyl-CoA …
