Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription
LI Zon, Y Yamaguchi, K Yee, EA Albee, A Kimura… - 1993 - ashpublications.org
1993•ashpublications.org
The expression of the hematopoietic transcription factors GATA-1, GATA-2, and GATA-3 was
studied in eosinophils and basophils. Eosinophils express mRNA for GATA-1, GATA-2, and
GATA-3. Basophils express GATA-2 and GATA-3. Treatment of HL-60 eosinophilic sublines
with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA
concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2
mRNA remained relatively constant. The presence of mRNA for these proteins in …
studied in eosinophils and basophils. Eosinophils express mRNA for GATA-1, GATA-2, and
GATA-3. Basophils express GATA-2 and GATA-3. Treatment of HL-60 eosinophilic sublines
with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA
concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2
mRNA remained relatively constant. The presence of mRNA for these proteins in …
Abstract
The expression of the hematopoietic transcription factors GATA-1, GATA- 2, and GATA-3 was studied in eosinophils and basophils. Eosinophils express mRNA for GATA-1, GATA-2, and GATA-3. Basophils express GATA-2 and GATA-3. Treatment of HL-60 eosinophilic sublines with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2 mRNA remained relatively constant. The presence of mRNA for these proteins in eosinophils and basophils suggests that gene transcription in these lineages may be regulated by GATA-binding proteins.
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