Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters: identification of N-linked glycosylation …
S Bungert, LL Molday, RS Molday - Journal of Biological Chemistry, 2001 - ASBMB
ABCR is a member of the ABCA subclass of ATP binding cassette transporters that is
responsible for Stargardt macular disease and implicated in retinal transport across
photoreceptor disc membranes. It consists of a single polypeptide chain arranged in two
tandem halves, each having a multi-spanning membrane domain followed by a nucleotide
binding domain. To delineate between several proposed membrane topological models, we
have identified the exocytoplasmic (extracellular/lumen) N-linked glycosylation sites on …
responsible for Stargardt macular disease and implicated in retinal transport across
photoreceptor disc membranes. It consists of a single polypeptide chain arranged in two
tandem halves, each having a multi-spanning membrane domain followed by a nucleotide
binding domain. To delineate between several proposed membrane topological models, we
have identified the exocytoplasmic (extracellular/lumen) N-linked glycosylation sites on …
