[HTML][HTML] Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1
K Ebnet, CU Schulz, MKM zu Brickwedde… - Journal of Biological …, 2000 - ASBMB
We have identified the PDZ domain protein AF-6 as an intracellular binding partner of the
junctional adhesion molecule (JAM), an integral membrane protein located at cell contacts.
Binding of AF-6 to JAM required the presence of the intact C terminus of JAM, which
represents a classical type II PDZ domain-binding motif. Although JAM did not interact with
the single PDZ domains of ZO-1 or of CASK, we found that a ZO-1 fragment containing PDZ
domains 2 and 3 bound to JAM in vitro in a PDZ domain-dependent manner. AF-6 as well as …
junctional adhesion molecule (JAM), an integral membrane protein located at cell contacts.
Binding of AF-6 to JAM required the presence of the intact C terminus of JAM, which
represents a classical type II PDZ domain-binding motif. Although JAM did not interact with
the single PDZ domains of ZO-1 or of CASK, we found that a ZO-1 fragment containing PDZ
domains 2 and 3 bound to JAM in vitro in a PDZ domain-dependent manner. AF-6 as well as …
