Transforming p21ras mutants and c-ets-2 activate the cyclin d1 promoter through distinguishable regions (∗)
C Albanese, J Johnson, G Watanabe, N Eklund… - Journal of Biological …, 1995 - ASBMB
Several different oncogenes and growth factors promote G 1 phase progression. Cyclin D1,
the regulatory subunit of several cyclin-dependent kinases, is required for, and capable of
shortening, the G 1 phase of the cell cycle. The present study demonstrates that transforming
mutants of p21 ras (Ras Val-12, Ras Leu-61) induce the cyclin D1 promoter in human
trophoblasts (JEG-3), mink lung epithelial (Mv1. Lu), and in Chinese hamster ovary fibroblast
cell lines. Site-directed mutagenesis of AP-1-like sequences at− 954 abolished p21 ras …
the regulatory subunit of several cyclin-dependent kinases, is required for, and capable of
shortening, the G 1 phase of the cell cycle. The present study demonstrates that transforming
mutants of p21 ras (Ras Val-12, Ras Leu-61) induce the cyclin D1 promoter in human
trophoblasts (JEG-3), mink lung epithelial (Mv1. Lu), and in Chinese hamster ovary fibroblast
cell lines. Site-directed mutagenesis of AP-1-like sequences at− 954 abolished p21 ras …
