Autoantibodies to the collagen-like region of C1Q deposit in glomeruli via C1Q in immune deposits
S Uwatoko, VJ Gauthier, M Mannik - Clinical immunology and …, 1991 - Elsevier
The autoantibodies to the collagen-like region of C1q (CLR), purified from two patients with
systemic lupus erythematosus, deposited in mouse glomeruli when human C1q was present
in antigen-antibody complexes in glomeruli. The immune deposits with C1q in mouse
glomeruli were achieved by the administration of cationized immune complexes containing
human C1q. The presented data suggest that the autoantibodies to CLR could enhance the
pathogenic role of immune complexes deposited in glomeruli by binding to C1q in immune …
systemic lupus erythematosus, deposited in mouse glomeruli when human C1q was present
in antigen-antibody complexes in glomeruli. The immune deposits with C1q in mouse
glomeruli were achieved by the administration of cationized immune complexes containing
human C1q. The presented data suggest that the autoantibodies to CLR could enhance the
pathogenic role of immune complexes deposited in glomeruli by binding to C1q in immune …