NF-κB1 (p50) Homodimers Contribute to Transcription of thebcl-2 Oncogene
JF Kurland, R Kodym, MD Story, KB Spurgers… - Journal of Biological …, 2001 - ASBMB
The bcl-2 proto-oncogene is frequently expressed in human cancer. Although bcl-2 was first
cloned as the t (14; 18) translocation breakpoint from human follicular B-cell lymphoma, it
has become apparent that many cell types express bcl-2 because of transcriptional
regulation. As such, several transcription factors have been demonstrated to activate
expression of bcl-2, including NF-κB. We investigated the role of NF-κB1 (p50) homodimers
in the expression of Bcl-2 in two murine B-cell lymphoma cell lines: LY-as, an apoptosis …
cloned as the t (14; 18) translocation breakpoint from human follicular B-cell lymphoma, it
has become apparent that many cell types express bcl-2 because of transcriptional
regulation. As such, several transcription factors have been demonstrated to activate
expression of bcl-2, including NF-κB. We investigated the role of NF-κB1 (p50) homodimers
in the expression of Bcl-2 in two murine B-cell lymphoma cell lines: LY-as, an apoptosis …
