Hyperoxia inhibits oxidant-induced apoptosis in lung epithelial cells
WR Franek, S Horowitz, L Stansberry, JA Kazzaz… - Journal of Biological …, 2001 - ASBMB
It has previously been shown that hyperoxia induces nonapoptotic cell death in cultured
lung epithelial cells, whereas hydrogen peroxide (H 2 O 2) and paraquat cause apoptosis.
To test whether pathways leading to oxidative apoptosis in epithelial cells are sensitive to
molecular O 2, A549 cells were exposed to 95% O 2 prior to exposure to lethal
concentrations of H 2 O 2. The extent of H 2 O 2-induced apoptosis was significantly
reduced in cells preexposed to hyperoxia compared with room-air controls. Preexposure of …
lung epithelial cells, whereas hydrogen peroxide (H 2 O 2) and paraquat cause apoptosis.
To test whether pathways leading to oxidative apoptosis in epithelial cells are sensitive to
molecular O 2, A549 cells were exposed to 95% O 2 prior to exposure to lethal
concentrations of H 2 O 2. The extent of H 2 O 2-induced apoptosis was significantly
reduced in cells preexposed to hyperoxia compared with room-air controls. Preexposure of …
