[HTML][HTML] Nuclear factor-κB is activated by hyperoxia but does not protect from cell death
Y Li, W Zhang, LL Mantell, JA Kazzaz, AM Fein… - Journal of Biological …, 1997 - ASBMB
Oxidative insults that are lethal to epithelial cells kill either via apoptosis or necrosis. Nuclear
factor-κB (NF-κB) is a redox-sensitive transcription factor that is activated by oxidative insult,
and NF-κB activation can protect cells from apoptosis. To test if NF-κB can protect from
necrotic cell death caused by high levels of molecular O 2 (hyperoxia), we exposed human
alveolar epithelial (A549) cells to hyperoxia. NF-κB was shown to be activated and was
translocated to the nucleus within minutes. Nuclear translocation persisted over the course …
factor-κB (NF-κB) is a redox-sensitive transcription factor that is activated by oxidative insult,
and NF-κB activation can protect cells from apoptosis. To test if NF-κB can protect from
necrotic cell death caused by high levels of molecular O 2 (hyperoxia), we exposed human
alveolar epithelial (A549) cells to hyperoxia. NF-κB was shown to be activated and was
translocated to the nucleus within minutes. Nuclear translocation persisted over the course …
